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AGA JAMES W. FRESTON CONFERENCE

Bringing Cutting-Edge Research to the Forefront

Extracellular Vesicles — Biology, Translation and Clinical Application in GI Disorders

Sept. 9 & 10, 2017 • St. Paul, MN
Funded by the Takeda Endowment in support of the James W. Freston Single Topic Conference.
Register Now
Cutting-edge research and innovative insight await you at the 2017 Freston conference. This is your opportunity to engage the foremost investigators in GI and extracellular vesicles (EVs) and delve deeper into vesicle biogenesis and secretion — revealing its relevance to GI diseases and clinical applications.

Explore Novel Research

Gain insight on the latest basic and translational research to better understand the role of EVs in disease pathogenesis.

Engage in Scientific Dialogue

Speak with experienced and up-and-coming researchers about the diagnostic and therapeutic potential of EVs.

Foster Collaboration

Connect with more than 100 researchers from multiple therapeutic areas to expand your network.

Influence Future Research

Discuss the evolving progress of EV research and help identify critical areas where further study is needed.

Pricing

Register early to receive a significant discount and reserve your spot at the conference. Online registration ends Friday, Aug. 25, 2017. After this date, only on-site registrations will be permitted. Registrations made on site are subject to the availability of space.

Early Bird

By June 14
$380/AGA Members
  • Nonmembers: $480
  • AGA Member Trainee/Student: $80

On Site

Sept. 9 – Sept. 10
$530/AGA Members
  • Nonmembers: $630
  • AGA Member Trainee/Student: $180

Not an AGA member?

Submit a completed membership application with your course registration and pay the AGA member rate.

*If applying for AGA membership, your application must be received no later than June 7, 2017, to qualify for the AGA member early rate.

**If applying for AGA membership, your application must be received no later than Aug. 14, 2017, to qualify for the AGA member standard rate.

Cancellation Policy

A refund (minus a $50 processing fee) will be given for cancellations received in writing on or before Friday, Aug. 25, 2017. Please send requests to AGA Member Relations via email (member@gastro.org), fax (301-272-1774) or mail (4930 Del Ray Avenue, Bethesda, MD 20814).

No cancellations will be accepted for refunds after Aug. 25, 2017. Refunds cannot be made for no shows.

Key Questions Examined

How are extracellular vesicles released from apical and basolateral membrane domains of epithelial cells?
What role do extracellular vesicles play in obesity and cell migration?
How are extracellular vesicles helping in the diagnosis of cancer?
What extracellular-based therapies are currently being developed in GI disorders?

Agenda

Saturday, Sept. 9

7-8 a.m. Registration and Breakfast
Session 1 — Discovery: Biogenesis and Secretion

Moderators: Nicholas F. LaRusso, MD, AGAF, and Harmeet Malhi, MBBS

8–8:15 a.m. Welcome and Opening Remarks
Nicholas F. LaRusso, MD, AGAF
8:15–9 a.m. Keynote Address: EV in GI Tumorigenesis
David Lyden, MD, PhD
9–9:30 a.m. Biogenesis, Secretion and Characterization of EV Population
Clotilde Thery, PhD
9:30–10 a.m. Biogenesis and Secretion of Exosomes from Polarized Epithelia
David J. Katzmann, PhD
10–10:30 a.m. Protein Sorting into EV
John P. Nolan, PhD
10:30–11 a.m. Coffee Break
Session 2 — Discovery: Biogenesis and Secretion (Cont'd)

Moderators: Clotilde Thery, PhD, and Alissa Weaver, PhD

11–11:30 a.m. EGFR and Its Ligands in Exosomes
Jeffrey L. Franklin, PhD
11:30 a.m.–noon Lipids in EV Biogenesis
Harmeet Malhi, MBBS
Noon–12:30 p.m. Domain-Specific Secretion of Exosomes from Polar Epithelia
Nicholas F. LaRusso, MD, AGAF
12:30-1:30 p.m. Lunch
Session 3 — Translation: Disease Relevance

Moderators: Jeffrey L. Franklin, PhD, and Gregory Gores, MD, AGAF

1:30–2 p.m. Mechanisms of EV Released by Stressed Hepatocytes
Gregory J. Gores, MD, AGAF
2–2:30 p.m. Immune Regulation by EV in Liver Disease Models
Gyongyi Szabo, MD, PhD, AGAF
2:30–3 p.m. Bacterial Microvesicles: Communication Pathways in the Gut-Brain Axis
John Bienenstock, MD, FRCP
3–3:30 p.m. Coffee Break
Session 4 — Translation: Disease Relevance (Cont'd)

Moderators: David Lyden, MD, PhD, and Gyongyi Szabo, MD, PhD, AGAF

3:30–4 p.m. EV in Obesity
Robert J. Freishtat, MD, MPH
4–4:30 p.m. EV Regulation of Directional Cell Migration
Alissa Weaver, MD, PhD
4:30–4:40 p.m. Abstract Presentation: Results from High Resolution Gradient Centrifugation of Exosomes Require Reassessment of their Composition*
Dennis K. Jeppesen
4:40–4:50 p.m. Abstract Presentation: STARD11-Mediated Ceramide Transport is Necessary for Release of Lipotoxic Extracellular Vesicles*
Masanori Fukushima
4:50–5 p.m. Abstract Presentation: Colorectal Cancer Extracellular Vesicles for Monitoring Tumor Recurrence*
Hon S. Leong
5–5:10 p.m. Abstract Presentation: mRNA Binding Protein IMP1 Enhances Exosome Production and Promotes Colorectal Cancer Metastasis*
Sarah F. Andres
5:10–5:20 p.m. Abstract Presentation: The RNA binding protein HuR Enhances Exosome Secretion in Colorectal Cancer*
Ranjan Preet
5:20–5:30 p.m. Abstract Presentation: Circulating Extracellular Microvesicles, A Novel Mechanism of Endocrine Cellular Cross-Talk, Are Increased in Newly Diagnosed Celiac Disease Patient*
Konstantinos Efthymakis
6-7:30 p.m. Dinner

Sunday, Sept. 10

7-8 a.m. Registration and Breakfast
Session 5 — Application: Diagnosis and Therapeutics

Moderators: Ariel E. Feldstein, MD, and John Bienenstock, MD, FRCP

8–8:30 a.m. EV miRNA: Liquid Biopsies for Disease Diagnosis
Tushar Patel, MBChB
8:30–9 a.m. Diagnostic Utility of EV in Pancreatic Cancer
Murray Korc, MD
9–9:30 a.m. Coffee Break
Session 6 — Application: Diagnosis and Therapeutics (Cont'd)

Moderator: Tushar Patel, MD, NMChB, and Murray Korc, MD

9:30–10 a.m. EV-Based Therapy in GI Disease
Huang-Ge Zhang, MD, PhD
10–10:10 a.m. Abstract Presentation: LncRNAH19-Containing Exosomes from Cholangiocytes Promote Cholestatic Liver Injury in Mdr2 Knock Out Mice*
Xiaojiaoyang Li
10:10–10:20 a.m. Abstract Presentation: SHP2 Promotes Liver Fibrosis by Inducing Secretion of Hepatic Stellate Cell-Derived PDGFRα-Enriched Extracellular Vesicles*
Enis Kostallari
10:20–10:30 a.m. Abstract Presentation: Inflammasome-Mediated Caspase 1-Dependent Cleavage of the Rab7 Trafficking Adaptor RILP Leads to Increased Exosome Secretion in Inflammatory Liver Diseases*
Ann Wozniak
10:30–10:40 a.m. Abstract Presentation: The Secretin/Secretin Receptor Axis is Required for Cell-Cell Communication via Extracellular Vesicles Between Cholangiocytes During Biliary Inflammation*
Keisaku Sato
10:40–11:10 a.m. KRAS Dependent Sorting of RNA into Exosomes
James G. Patton, PhD
11:10–11:40 a.m. Circulating EV-Based Molecular Diagnostic
Ariel E. Feldstein, MD
11:40–11:50 a.m. Meeting Summary
Nicholas F. LaRusso, MD, AGAF
James G. Patton, PhD
Noon-1:30 p.m. Interactive Lunch
Poster Session

*Note: All oral presentations will also have a corresponding poster. These presentations are also italicized.

Abstract ID Abstract Title Speaker
001 Metastatic Efficiency is Dependent on Cell Volume Loss Due to Extracellular Vesicle Release During Cancer Cell Extravasation Hon S. Leong
002 Colorectal Cancer Extracellular Vesicles for Monitoring Tumor Recurrence Hon S. Leong
003 Oncosomes as a Novel Liquid Biopsy Biomarker for Quantifying Metastatic Cancer Dynamics in Real-Time Hon S. Leong
004 SHP2 Promotes Liver Fibrosis by Inducing Secretion of Hepatic Stellate Cell-Derived PDGFRα-Enriched Extracellular Vesicles Enis Kostallari
005 The Secretin/Secretin Receptor Axis is Required for Cell-Cell Communication Via Extracellular Vesicles Between Cholangiocytes During Biliary Inflammation Keisaku Sato
006 Amelioration of Fibrosis and Inflammation by Stem Cell-Derived Extracellular Vesicles in a Mouse Model of Primary Sclerosing Cholangitis Kelly McDaniel
007 STARD11-Mediated Ceramide Transport is Necessary for Release of Lipotoxic Extracellular Vesicles Masanori Fukushima
008 Optimized Isolation of Plasma Extracellular Vesicles for Use as Postential Biomarkers in Patients with Glioblastoma Luz Milbeth Cumba Garcia
009 LncRNAH19-Containing Exosomes from Cholangiocytes Promote Cholestatic Liver Injury in Mdr2 Knock Out Mice Xiaojiaoyang Li
010 Inflammasome-Mediated Caspase 1-Dependent Cleavage of the Rab7 Trafficking Adaptor RILP Leads to Increased Exosome Secretion in Inflammatory Liver Diseases Ann Wozniak
011 The RNA Binding Protein HuR Enhances Exosome Secretion in Colorectal Cancer Ranjan Preet
012 Diverse Long-RNAs Are Differentially Expressed in Exosomes Secreted by Mutant KRAS Colecrectal Cancer Cells Scott A. Hinger
013 mRNA Binding Protein IMP1 Enhances Exosome Production and Promotes Colorectal Cancer Metastasis Sarah F. Andres
014 Exosomes from Mutant KRAS Colorectal Cancer Cells Reprogram the Metabolic State of Recipient Cells Jeffrey L. Franklin, MD
015 Results from High Resolution Gradient Centrifugation of Exosomes Require Reassessment of their Composition Dennis K. Jeppsen
016 Transfer of Functional St6Gal-I to Recipient Cells via Exosomes Qin Zhang
017 Using Fluorescence-Activated Vesicle Sorting (FAVS) to Monitor EGFR in Exosomes James N. Higginbotham
018 Circulating Extracellular Microvesicles, A Novel Mechanism of Endocrine Cellular Cross-Talk, Are Increased in Newly Diagnosed Celiac Disease Patient Konstantinos Efthymakis

Save up to $100 if you register by Aug. 25.

Faculty

Nicholas F. LaRusso, MD, AGAF

Nicholas F. LaRusso, MD, AGAF

Conference Co-Chair

Mayo Clinic
Robert J. Coffey, MD

Robert J. Coffey, MD

Conference Co-Chair

Vanderbilt University Medical Center

John Bienenstock, MD, FRCP
McMaster Brain-Body Institute at St. Joseph’s Healthcare Hamilton

Ariel E. Feldstein, MD
University of California, San Diego
Rady Children’s Hospital, San Diego
University of South Carolina

Jeffrey L. Franklin, PhD
Vanderbilt University Medical Center

Robert J. Freishtat, MD, MPH
Children’s National Medical Center

Gregory J. Gores, MD, AGAF
Mayo Clinic

 

 

David J. Katzmann, PhD
Mayo Clinic

Murray Korc, MD
Indiana University School of Medicine

David Lyden, MD, PhD
Weill Cornell Medicine

Harmeet Malhi, MBBS
Mayo Clinic

John P. Nolan, PhD
Scintillon Institute

Tushar Patel, MBChB
Mayo Clinic

 

James G. Patton, PhD
Vanderbilt University

Gyongyi Szabo, MD, PhD
University of Massachusetts Medical School

Clotilde Thery, PhD
Institute Curie, INSERM U932

Alissa Weaver, MD, PhD
Vanderbilt University

Huang-Ge Zhang, MD, PhD
University of Louisville

Share Your Research

Abstracts are no longer being accepted.

Accommodations

InterContinental St. Paul Riverfront

Located at 11 East Kellogg Blvd., St. Paul, MN 55101, room blocks have been reserved for attendees of the AGA James W. Freston Conference.

Room Rate

$155 single/double per night, plus applicable taxes.

Reservations

You may make your hotel reservation by calling 1-866-686-2867. Be sure to mention you are attending the 2017 AGA James W. Freston Conference to receive the discounted rate. Reservations must be guaranteed with a major credit card equal to one night’s room and tax.

Deadline

Rooms must be reserved by Friday, Aug. 18 to ensure availability and the discounted rate.

Cancellation

Cancellations must be made 72 hours prior to arrival in order to avoid charges for the first night’s room and tax. Reservations may only be cancelled by calling the hotel directly at 1-800-424-6835, or 651-605-0197, and obtaining a cancellation number. No-shows will be charged first night’s room and tax.

Intercontinental St. Paul Riverfront

InterContinental St. Paul Riverfront

Accreditation and CME Information

The AGA Institute designates this live activity for a maximum of 12 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Contact Us

For questions related to the program, contact Jamie Parreco, director of council operations.

For questions related to registration and AGA membership, contact AGA Member Relations at 301-654-2055 or by email.

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301-654-2055

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4930 Del Ray Ave.
Bethesda, MD 20814

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